Enitome E Bafor1
,
Osamuyi H Uwumarongie2,
Anthonia Omoregbe1
For correspondence:- Enitome Bafor Email: enitome.bafor@uniben.edu Tel: +2347080096949
Published: 30 December 2014
Citation: Bafor EE, Uwumarongie OH, Omoregbe A. Antipyretic Activity of Orally Administered Extracts of Newbouldia laevis (Bignonaceae) in Mice. J Sci Pract Pharm 2014; 1(1):7-10 doi: 10.47227/jsppharm.v1i1.2
© 2014 The author(s).
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Purpose: Several plant species are used in the management and treatment of pyrexia. In this study, the antipyretic activity of extracts of Newbouldia laevis leaves was investigated on normal body temperature and baker’s yeast induced pyrexia in mice.
Methods: The crude leaves were extracted with water, ethyl acetate and hexane. Pyrexia was induced with baker’s yeast at a dose of 10 ml/kg of 30% w/v and the extracts were orally administered to groups of mice at 25, 50 and 100 mg/kg while 0.9% NaCl and paracetamol (20 mg/kg) were also administered and served as controls. The effect of the extracts on normal body temperature was assessed.
Results: Unlike the hexane extract, the aqueous and ethyl acetate extracts displayed significant antipyretic properties at all doses employed (p<0.05) but no significant effect on normal body temperature of the mice was observed similar to the effect of paracetamol.
Conclusion: Extract of the leaves of N. laevis exert antipyretic effects and these results support claims by traditional medicine healers for its use in fever reduction
